Opioids and cannabinoids are a group of endogenous and exogenous compounds that function through activation of their respective receptors (opioid
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Combined vapor exposure to THC and alcohol in pregnant rats: Maternal outcomes and pharmacokinetic effects
Cannabis is the most frequently used illicit drug among pregnant women, yet the potential consequences of prenatal cannabis exposure on
Transdermal cannabidiol reduces inflammation and pain-related behaviours in a rat model of arthritis
Background: Current arthritis treatments often have side-effects attributable to active compounds as well as route of administration. Cannabidiol (CBD) attenuates
Palmitoylethanolamide, endocannabinoids and related cannabimimetic compounds in protection against tissue inflammation and pain: potential use in companion animals
Endocannabinoids have analgesic/anti-inflammatory properties. The biology of endocannabinoids, their receptors, signalling mechanisms and role in the regulation of physiological processes
Cannabidiol, a major non-psychotropic cannabis constituent enhances fracture healing and stimulates hydroxylase activity in osteoblasts
Cannabinoid ligands regulate bone mass, but skeletal effects of cannabis (marijuana and hashish) have not been reported. Bone fractures are
Delta-9-tetrahydrocannabinolic acid alleviates collagen-induced arthritis: Role of PPARy and CB1 receptors
Background and Purpose Δ9-Tetrahydrocannabinolic acid (Δ9-THCA-A), the precursor of Δ9-THC, is a non-psychotropic phytocannabinoid that shows PPARγ agonist activity. Here,
Oral Transmucosal Cannabidiol Oil Formulation as Part of a Multimodal Analgesic Regimen: Effects on Pain Relief and Quality of Life Improvement in Dogs Affected by Spontaneous Osteoarthritis
The aim of this study was to evaluate the efficacy of oral transmucosal (OTM) cannabidiol (CBD), in addition to a
Evaluation of the Effect of Cannabidiol on Naturally Occurring Osteoarthritis-Associated Pain: A Pilot Study in Dogs
The objective of this study was to provide preliminary data describing the safety and effect of cannabidiol (CBD) for symptom
Effects of a topically applied 2% delta-9-tetrahydrocannabinol ophthalmic solution on intraocular pressure and aqueous humor flow rate in clinically normal dogs.
Objective—To determine the effects of topically applied 2% delta-9-tetrahydrocannabinol (THC) ophthalmic solution on aqueous humor flow rate (AHFR) and intraocular
Cannabidiol Induces Apoptosis and Perturbs Mitochondrial Function in Human and Canine Glioma Cells
Cannabidiol (CBD), the major non-psychoactive compound found in cannabis, is frequently used both as a nutraceutical and therapeutic. Despite anecdotal
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