Abstract Orally applicable Delta9-tetrahydrocannabinol and its synthetic derivatives have been used as antiemetic drugs during chemotherapy in cancer patients. However,
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GPR55 signalling promotes proliferation of pancreatic cancer cells and tumour growth in mice, and its inhibition increases effects of gemcitabine
Abstract The life expectancy for pancreatic cancer patients has seen no substantial changes in the last 40 years as very
Gemcitabine/cannabinoid combination triggers autophagy in pancreatic cancer cells through a ROS-mediated mechanism
Abstract Gemcitabine (GEM, 2′,2′-difluorodeoxycytidine) is currently used in advanced pancreatic adenocarcinoma, with a response rate of < 20%. The purpose
Ganoderma: A Cancer Immunotherapy Review
Abstract Ganoderma is a significant source of natural fungal medicines and has been used for the treatment of various diseases for
Antitumor Cannabinoid Chemotypes: Structural Insights
Abstract Cannabis has long been known to limit or prevent nausea and vomiting, lack of appetite, and pain. For this
The heterogeneity and complexity of Cannabis extracts as antitumor agents
Abstract The Cannabis plant contains over 100 phytocannabinoids and hundreds of other components. The biological effects and interplay of these Cannabis compounds are not
Potency Assessment of CBD Oils by Their Effects on Cell Signaling Pathways
Abstract This study used nanofluidic protein posttranslational modification (PTM) profiling to measure the effects of six cannabidiol (CBD) oils and
Colon carcinogenesis is inhibited by the TRPM8 antagonist cannabigerol, a Cannabis- derived non-psychotropic cannabinoid
Abstract Cannabigerol (CBG) is a safe non-psychotropic Cannabis-derived cannabinoid (CB), which interacts with specific targets involved in carcinogenesis. Specifically, CBG
Flavonoid Derivative of Cannabis Demonstrates Therapeutic Potential in Preclinical Models of Metastatic Pancreatic Cancer
Abstract Pancreatic cancer is particularly refractory to modern therapies, with a 5-year survival rate for patients at a dismal 8%.
Enhancing the Therapeutic Efcacy of Cancer Treatment With Cannabinoids
Abstract Over the years, many in vitro and in vivo studies have shown the antineoplastic effects of cannabinoids (CBDs), with reports advocating for investigations
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