Abstract The ATP-dependent drug efflux transporter P-glycoprotein (P-gp) plays a significant role in the absorption and disposition of many compounds.
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CB2 and TRPV1 receptors mediate cannabinoid actions on MDR1 expression in multidrug resistant cells
Abstract Background: Cannabis is the most widely used illicit drug in the world that is often used by cancer patients in
Cannabis extract treatment for terminal acute lymphoblastic leukemia with a Philadelphia chromosome mutation
Abstract Acute lymphoblastic leukemia (ALL) is a cancer of the white blood cells and is typically well treated with combination
Cannabidiol Reduces Leukemic Cell Size – But Is It Important?
Abstract The anti-cancer effect of the plant-derived cannabinoid, cannabidiol, has been widely demonstrated both in vivo and in vitro. However, this body of
In vitro and in vivo efficacy of non-psychoactive cannabidiol in neuroblastoma
Abstract Background: Neuroblastoma (nbl) is one of the most common solid cancers in children. Prognosis in advanced nbl is still poor
A pilot clinical study of Δ -tetrahydrocannabinol in patients with recurrent glioblastoma multiforme
Abstract Delta(9)-Tetrahydrocannabinol (THC) and other cannabinoids inhibit tumour growth and angiogenesis in animal models, so their potential application as antitumoral
A combined preclinical therapy of cannabinoids and temozolomide against glioma
Abstract Glioblastoma multiforme (GBM) is highly resistant to current anticancer treatments, which makes it crucial to find new therapeutic strategies
The use of cannabis in supportive care and treatment of brain tumor
Abstract Cannabinoids are multitarget substances. Currently available are dronabinol (synthetic delta-9-tetrahydrocannabinol, THC), synthetic cannabidiol (CBD) the respective substances isolated and
The Medical Necessity for Medicinal Cannabis: Prospective, Observational Study Evaluating the Treatment in Cancer Patients on Supportive or Palliative Care
Abstract Background. Cancer patients using cannabis report better influence from the plant extract than from synthetic products. However, almost all
The endocannabinoid system: Novel targets for treating cancer induced bone pain
Abstract Treating Cancer-induced bone pain (CIBP) continues to be a major clinical challenge and underlying mechanisms of CIBP remain unclear.
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