Abstract Background: Clinical trials investigating the use of cannabinoid drugs for the treatment of intestinal inflammation are anticipated secondary to preclinical
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Anti-Inflammatory Activity in Colon Models Is Derived from D9-Tetrahydrocannabinolic Acid That Interacts with Additional Compounds in Cannabis Extracts
Abstract Introduction: Inflammatory bowel diseases (IBDs) include Crohn’s disease, and ulcerative colitis. Cannabis sativa preparations have beneficial effects for IBD patients. However, C. sativa extracts
Gemcitabine/cannabinoid combination triggers autophagy in pancreatic cancer cells through a ROS-mediated mechanism
Abstract Gemcitabine (GEM, 2′,2′-difluorodeoxycytidine) is currently used in advanced pancreatic adenocarcinoma, with a response rate of < 20%. The purpose
Gastric cytoprotection of the non-steroidal anti-inflammatory sesquiterpene, beta-caryophyllene
Abstract The gastric cytoprotective effect of beta-caryophyllene, an anti-inflammatory sesquiterpene, was investigated in rats. The oral administration of beta-caryophyllene to
Cannabis and Turmeric as Complementary Treatments for IBD and Other Digestive Diseases
Abstract Purpose of review: Complementary therapies for inflammatory bowel disease (IBD) have earned growing interest from patients and investigators alike, with
The Role of the Endocannabinoid System in the Brain-Gut Axis
Abstract The actions of cannabis are mediated by receptors that are part of an endogenous cannabinoid system. The endocannabinoid system
Cannabinoid pharmacology and therapy in gut disorders
Abstract Cannabis sp. and their products (marijuana, hashish…), in addition to their recreational, industrial and other uses, have a long
Cannabis, Cannabinoids, and the Endocannabinoid System—Is there Therapeutic Potential for Inflammatory Bowel Disease?
Abstract Cannabis sativa and its extracts have been used for centuries, both medicinally and recreationally. There is accumulating evidence that exogenous
Enterocolic increase of cannabinoid receptor type 1 and type 2 and clinical improvement after probiotic administration in dogs with chronic signs of colonic dysmotility without mucosal inflammatory changes
Abstract Background Colonic dysmotility in dogs can cause different GI signs. Sometimes, histology of enterocolic biopsies does not reveal inflammatory
Thymol modulates the endocannabinoid system and gut chemosensing of weaning pigs
Abstract Background The recent identification of the endocannabinoid system in the gastrointestinal tract suggests a role in controlling intestinal inflammation.
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