Multi targets of cannabidiol (CBD) on skeletal mammalian and avian neuromuscular preparations
Cannabidiol (CBD) has been used in diseases that affect the central nervous system. Its effects on the peripheral synapses are...
Non-Psychoactive Cannabinoid Modulation of Nociception and Inflammation Associated with a Rat Model of Pulpitis
Apr 17, 2024
Despite advancements in dental pain management, one of the most common reasons for emergency dental care is orofacial pain. Our...
Attenuation of early phase inflammation bycannabidiol prevents pain and nerve damage inrat osteoarthritis
Oct 18, 2023
Osteoarthritis (OA) is a multifactorial joint disease, which includes joint degeneration, intermittent inflammation, and peripheral neuropathy. Cannabidiol (CBD) is a...
Cannabidiol improves brain and liver function in a fulminant hepatic failure-induced model of hepatic encephalopathy in mice
Oct 18, 2023
Abstract Background and purpose: Hepatic encephalopathy is a neuropsychiatric disorder of complex pathogenesis caused by acute or chronic liver failure....
Comparison of Acute Oral Toxicity of Cannabinoids in Rats, Dogs and Monkeys
Oct 18, 2023
Comparison of acute oral toxicity of cannabinoids in rats, dogs and monkeys
Feeding decreases the oral bioavailability ofcannabidiol and cannabidiolic acid in hemp oil inNew Zealand White rabbits (Oryctolagus cuniculus)
Oct 18, 2023
Abstract Objective: To determine the pharmacokinetics of a solution containing cannabidiol (CBD) and cannabidiolic acid (CBDA), administered orally in 2...
Cannabinoid receptor 2 evolutionary gene loss makes parrots more susceptible to neuroinflammation
Oct 18, 2023
In vertebrates, cannabinoids modulate neuroimmune interactions through two cannabinoid receptors (CNRs) conservatively expressed in the brain (CNR1, syn. CB1) and...
Local interactions between anandamide, an endocannabinoid, and ibuprofen, a nonsteroidal anti-inflammatory drug, in acute and inflammatory pain
Sep 21, 2022
Abstract Anandamide, an endocannabinoid, is degraded by the enzyme fatty acid amide hydrolase which can be inhibited by nonsteroidal anti-inflammatory...
Combined vapor exposure to THC and alcohol in pregnant rats: Maternal outcomes and pharmacokinetic effects
Aug 10, 2022
Cannabis is the most frequently used illicit drug among pregnant women, yet the potential consequences of prenatal cannabis exposure on...
The Impact of Cannabidiol on the Induction of Isoflurane Anesthesia and Recovery in Wistar Rats
Aug 10, 2022
Background: Beside others, neuroinhibitory and sedative effects of CBD were documented. Aim and Methods: The aim of the study was...
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