Modulating the endocannabinoid system in human health and disease: successes and failures
Abstract The discovery of the endocannabinoid system, comprising the G-protein coupled cannabinoid 1 and 2 receptors (CB1/2), their endogenous lipid...
Development of Standard Operating Protocols for the Optimization of Cannabis-Based Formulations for Medical Purposes
Apr 21, 2021
Abstract Under current legislation in Italy, Cannabis for medical purposes may be administered orally in the form of decoction or Cannabis oil extract. The...
Possible Drug–Drug Interactions Between Cannabinoids and Candidate COVID-19 Drugs
Apr 21, 2021
Introduction Cannabinoid preparations are available across the globe as regulatory agency-approved medicines, through medical cannabis programs, and as hemp-derived products....
Marijuana as Medicine?: The Science Beyond the Controversy
Apr 21, 2021
Excerpt Some people suffer from chronic, debilitating disorders for which no conventional treatment brings relief. Can marijuana ease their symptoms?...
The Case for the Entourage Effect and Conventional Breeding of Clinical Cannabis: No “Strain,” No Gain
Apr 21, 2021
Abstract The topic of Cannabis curries controversy in every sphere of influence, whether politics, pharmacology, applied therapeutics or even botanical...
Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects
Apr 21, 2021
Abstract Tetrahydrocannabinol (THC) has been the primary focus of cannabis research since 1964, when Raphael Mechoulam isolated and synthesized it....
Cannabis sativa: The Plant of the Thousand and One Molecules
Apr 20, 2021
Abstract Cannabis sativa L. is an important herbaceous species originating from Central Asia, which has been used in folk medicine and...
Is Cannabidiol a Promising Substance for New Drug Development? A Review of its Potential Therapeutic Applications
Apr 20, 2021
Abstract The pharmacological importance of cannabidiol (CBD) has been in study for several years. CBD is the major nonpsychoactive constituent...
An Update on Safety and Side Effects of Cannabidiol: A Review of Clinical Data and Relevant Animal Studies
Apr 20, 2021
Abstract Introduction: This literature survey aims to extend the comprehensive survey performed by Bergamaschi et al. in 2011 on cannabidiol (CBD)...
The use of cannabinoids in animals and therapeutic implications for veterinary medicine: A review
Apr 20, 2021
Abstract Cannabinoids/medical marijuana and their possible therapeutic use have received increased attention in human medicine during the last years. This...
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