The heterogeneity and complexity of Cannabis extracts as antitumor agents
Abstract The Cannabis plant contains over 100 phytocannabinoids and hundreds of other components. The biological effects and interplay of these Cannabis compounds are not...
Potency Assessment of CBD Oils by Their Effects on Cell Signaling Pathways
Apr 21, 2021
Abstract This study used nanofluidic protein posttranslational modification (PTM) profiling to measure the effects of six cannabidiol (CBD) oils and...
Enhancing the Therapeutic Efcacy of Cancer Treatment With Cannabinoids
Apr 21, 2021
Abstract Over the years, many in vitro and in vivo studies have shown the antineoplastic effects of cannabinoids (CBDs), with reports advocating for investigations...
Cannabinoids, Endocannabinoids and Cancer
Apr 21, 2021
Abstract The endocannabinoid system consists of an array of endogenously produced bioactive lipids that activate cannabinoid receptors. Although the primary...
Cannabinoids for cancer treatment: progress and promise
Apr 21, 2021
Abstract Cannabinoids are a class of pharmacologic compounds that offer potential applications as antitumor drugs, based on the ability of...
Cannabinoids and Cancer
Apr 21, 2021
Abstract Marijuana has been used in medicine for millennia, but it was not until 1964 that delta9-tetrahydrocannabinol (delta9-THC), its major...
Cannabinoid receptor-independent cytotoxic effects of cannabinoids in human colorectal carcinoma cells: synergism with 5-fluorouracil.
Apr 21, 2021
Abstract Cannabinoids (CBs) have been found to exert antiproliferative effects upon a variety of cancer cells, including colorectal carcinoma cells....
Cannabidiol, a Non-Psychoactive Cannabinoid Compound, Inhibits Proliferation and Invasion in U87-MG and T98G Glioma Cells through a Multitarget Effect
Apr 21, 2021
Abstract In the present study, we found that CBD inhibited U87-MG and T98G cell proliferation and invasiveness in vitro and...
Characterization of P-glycoprotein inhibition by major cannabinoids from marijuana.
Apr 21, 2021
Abstract The ATP-dependent drug efflux transporter P-glycoprotein (P-gp) plays a significant role in the absorption and disposition of many compounds....
The endocannabinoid system: Novel targets for treating cancer induced bone pain
Apr 21, 2021
Abstract Treating Cancer-induced bone pain (CIBP) continues to be a major clinical challenge and underlying mechanisms of CIBP remain unclear....
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