Overcoming the Bell‐Shaped Dose‐Response of Cannabidiol by Using Cannabis Extract Enriched in Cannabidiol
ABSTRACT Cannabidiol (CBD), a major constituent of Cannabis, has been shown to be a powerful anti-in- flammatory and anti-anxiety drug,...
α2-Adrenoceptor agonist induces peripheral antinociception via the endocannabinoid system
Apr 21, 2021
Abstract Background Xylazine is an α2 adrenoceptor agonist that is extensively used in veterinary medicine and animal experimentation procedures to produce...
GPR55 signalling promotes proliferation of pancreatic cancer cells and tumour growth in mice, and its inhibition increases effects of gemcitabine
Apr 21, 2021
Abstract The life expectancy for pancreatic cancer patients has seen no substantial changes in the last 40 years as very...
The Endocannabinoid System and Autism Spectrum Disorders: Insights from Animal Models
Apr 21, 2021
Abstract Autism spectrum disorder (ASD) defines a group of neurodevelopmental disorders whose symptoms include impaired communication and social interaction with...
Gemcitabine/cannabinoid combination triggers autophagy in pancreatic cancer cells through a ROS-mediated mechanism
Apr 20, 2021
Abstract Gemcitabine (GEM, 2′,2′-difluorodeoxycytidine) is currently used in advanced pancreatic adenocarcinoma, with a response rate of < 20%. The purpose...
Gastric cytoprotection of the non-steroidal anti-inflammatory sesquiterpene, beta-caryophyllene
Apr 20, 2021
Abstract The gastric cytoprotective effect of beta-caryophyllene, an anti-inflammatory sesquiterpene, was investigated in rats. The oral administration of beta-caryophyllene to...
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