Cannabitwinol, a Dimeric Phytocannabinoid from Hemp, Cannabis sativa L., Is a Selective Thermo-TRP Modulator
Cannabitwinol (CBDD, 3), the second member of a new class of dimeric phytocannabinoids in which two units are connected by...
Cannabinoid pharmacology: the first 66 years
Sep 28, 2021
Abstract Context: Research into the pharmacology of individual cannabinoids that began in the 1940s, several decades after the presence of a...
The pharmacology of cannabinoid receptors and their ligands: an overview
Apr 21, 2021
Abstract Mammalian tissues express at least two cannabinoid receptor types, CB1 and CB2, both G protein coupled. CB1 receptors are found predominantly...
Pharmacological synergism between cannabinoids and paclitaxel in gastric cancer cell lines
Apr 21, 2021
Abstract Orally applicable Delta9-tetrahydrocannabinol and its synthetic derivatives have been used as antiemetic drugs during chemotherapy in cancer patients. However,...
Potency Assessment of CBD Oils by Their Effects on Cell Signaling Pathways
Apr 21, 2021
Abstract This study used nanofluidic protein posttranslational modification (PTM) profiling to measure the effects of six cannabidiol (CBD) oils and...
Colon carcinogenesis is inhibited by the TRPM8 antagonist cannabigerol, a Cannabis- derived non-psychotropic cannabinoid
Apr 21, 2021
Abstract Cannabigerol (CBG) is a safe non-psychotropic Cannabis-derived cannabinoid (CB), which interacts with specific targets involved in carcinogenesis. Specifically, CBG...
Cannabinoids, Endocannabinoids and Cancer
Apr 21, 2021
Abstract The endocannabinoid system consists of an array of endogenously produced bioactive lipids that activate cannabinoid receptors. Although the primary...
Cannabinoids for cancer treatment: progress and promise
Apr 21, 2021
Abstract Cannabinoids are a class of pharmacologic compounds that offer potential applications as antitumor drugs, based on the ability of...
NSAIDs, Opioids, Cannabinoids and the Control of Pain by the Central Nervous System
Apr 21, 2021
Abstract Nonsteroidal anti-inflammatory drugs (NSAIDs) act upon peripheral tissues and upon the central nervous system to produce analgesia. A major...
Cannabinoid, Terpene, and Heavy Metal Analysis of 29 Over-the-Counter Commercial Veterinary Hemp Supplements
Apr 21, 2021
Abstract Purpose The use of veterinary low tetrahydrocannabinol (THC) Cannabis sativa (ie, hemp) products has increased in popularity for a variety of...
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