Characterization of P-glycoprotein inhibition by major cannabinoids from marijuana
Abstract The ATP-dependent drug efflux transporter P-glycoprotein (P-gp) plays a significant role in the absorption and disposition of many compounds....
Cannabinoids and Cytochrome P450 Interactions
Apr 21, 2021
Abstract Objective: This review consists of three parts, representing three different possibilities of interactions between cannabinoid receptor ligands of both exogenous...
A Report of Adverse Effects Associated with the Administration of Cannabindiol in Healthy Dogs
Apr 21, 2021
Abstract Cannabis-based therapies have been used for centuries for various medicinal purposes. They have recently gained recognition as an effective...
The pharmacology of cannabinoid receptors and their ligands: an overview
Apr 21, 2021
Abstract Mammalian tissues express at least two cannabinoid receptor types, CB1 and CB2, both G protein coupled. CB1 receptors are found predominantly...
Cannabis is more than simply Δ9-tetrahydrocannabinol
Apr 21, 2021
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The Endocannabinoid System as an Emerging Target of Pharmacotherapy
Apr 21, 2021
Abstract The recent identification of cannabinoid receptors and their endogenous lipid ligands has triggered an exponential growth of studies exploring...
Cannabis, a complex plant: different compounds and different effects on individuals
Apr 21, 2021
Abstract Cannabis is a complex plant, with major compounds such as delta-9-tetrahydrocannabinol and cannabidiol, which have opposing effects. The discovery...
The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: Δ9-tetrahydrocannabinol, cannabidiol and Δ9-tetrahydrocannabivarin
Apr 21, 2021
Abstract Cannabis sativa is the source of a unique set of compounds known collectively as plant cannabinoids or phytocannabinoids. This review...
α2-Adrenoceptor agonist induces peripheral antinociception via the endocannabinoid system
Apr 21, 2021
Abstract Background Xylazine is an α2 adrenoceptor agonist that is extensively used in veterinary medicine and animal experimentation procedures to produce...
Preliminary Investigation of the Safety of Escalating Cannabinoid Doses in Healthy Dogs
Apr 21, 2021
Abstract Objective: To determine the safety and tolerability of escalating doses of three cannabis oil formulations, containing predominantly CBD, THC, or...
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