• About Us
    • Our Team
    • Our Work
    • In The News
  • Resources
    • Curated Research Library
    • Popular Articles
    • Legal Beagle Archive
    • The Education Program
    • VCS Vet Research Program
  • Directory of Practitioners
  • Get Involved
    • Become A Sponsor
    • Join Email List
  • Contact
  • SHOP NOW
    • VCS APPAREL
    • PET & PARENT JEWELRY
  • DONATE
  • Members Dashboard
Veterinary Cannabis SocietyVeterinary Cannabis Society
  • About Us
    • Our Team
    • Our Work
    • In The News
  • Resources
    • Curated Research Library
    • Popular Articles
    • Legal Beagle Archive
    • The Education Program
    • VCS Vet Research Program
  • Directory of Practitioners
  • Get Involved
    • Become A Sponsor
    • Join Email List
  • Contact
  • SHOP NOW
    • VCS APPAREL
    • PET & PARENT JEWELRY
  • DONATE
  • Members Dashboard

Potential to use cannabinoids as adjunct therapy for dexamethasone: An in vitro study with canine peripheral blood mononuclear cells

Home Potential to use cannabinoids as adjunct therapy for dexamethasone: An in vitro study with canine peripheral blood mononuclear cells

Curated Research Library

  • Back to Curated Research Library

Potential to use cannabinoids as adjunct therapy for dexamethasone: An in vitro study with canine peripheral blood mononuclear cells

  • By: Sabrina Dixon, Arpita Deb, Todd Archer, Barbara L.F. Kaplan
  • Published On: 1 February, 2024
  • Publication: sciencedirect.com
  • Tags: canine
  • Category: Immunology

Dexamethasone (dex) is a potent glucocorticoid used to treat a variety of diseases. It is widely used in veterinary medicine in many species; for instance, in dogs, it can be used for emergent cases of anaphylaxis or trauma, management of immune-mediated hemolytic anemia or thrombocytopenia, certain cancers, allergic reactions, and topically for skin or eye inflammation. Dex is not without its side effects, especially when administered systemically, which might compromise compliance and effective treatment. Thus, adjunct therapies have been suggested to allow for decreased dex dosing and reduction in side effects while maintaining immunosuppressive efficacy. The goal of this study was to evaluate the potential for cannabinoids to serve as adjunct therapies for dex. Immune function was assessed in canine peripheral blood mononuclear cells (PBMCs) after treatment with dex with and without cannabidiol (CBD) and/or Δ9-tetrahydrocannabinol (THC). Dex suppressed IFN-γ protein secretion in a concentration-dependent manner and this suppression by low concentrations of dex was enhanced in the presence of CBD, THC, or the combination of CBD and THC. Similar effects were found with INFG and TNFA mRNA expression. These findings provide a rationale for using CBD or THC in vivo to reduce dex dosing and side effects.

Click Here to Access Article
  • Back to Curated Research Library
Search

Our Mission is to create lasting solutions that ensure the safe use of cannabis in pets through education, advocacy, and promoting product standards.

Our Vision is an educated and empowered global veterinary medical cannabis community.

  • About Us
  • Our Work
  • Get Involved
  • Contact Us
  • Donate

Email:
Click here to email us

Florida Mailing Address
7901 4th St. North, Suite 4404
St. Petersburg, FL 33702

Veterinary Cannabis Society is a nonprofit, 501(c)(3) organization in the United States. Tax ID #85-0986090

Veterinary Cannabis Society does not endorse any specific products.

© 2025 · Veterinary Cannabis Society

  • Terms of Use
  • Privacy Policy
  • State Notices
  • Contact